Dao Tan Tang on rat brain vascular endothelial cells of intercellular adhesion molecule -1.docVIP

 PAGE \* MERGEFORMAT 11 Dao Tan Tang on rat brain vascular endothelial cells of intercellular adhesion molecule -1 Study: Bin Chen Wenqiang Lizong Xin Huang Xiaobo Wang Ning Group [Abstract]: Objective Dao Tan Tang intervention cerebral vascular endothelial cell expression of intercellular adhesion molecule -1 (ICAM-1) expression were studied. Methods cerebral vascular endothelial cell culture, was observed by immunohistochemistry of tumor necrosis factor-@ ( TNF-@) in different time range (0 ~ 24 h) on endothelial cell expression of ICAM-1, and Dao Tan Tang intervention. Results role as time-TNF-@ increased ICAM-1 expression in endothelial cells was significantly increases, time-dependent manner, P lt;0.05. pre-treatment with Dao Tan Tang endothelial cells, ICAM-1 expression did not change significantly, compared with model group, P lt;0.05. Conclusion Dao Tan Tang can not simultaneously process TNF - @ induced expression of ICAM-1 play an inhibitory effect. [Keywords:] Dao Tan Tang cerebral vascular endothelial cells of rat intercellular adhesion molecule -1 Abstract: Objective To study the intervention of Daotan Decoction to the expression of ICAM-1 in cerebrovascular endothelial cells. Methods Cerebrovascular endothelial cells were cultured to observed the influence of ICAM-1 expression, which was induced by TNF-@, by the way of immunocytochemistry methods. Results Compared with control group, the expression of ICAM-1 in model group was time-dependent (P lt;0.05). And compared with model group, Daotan Decoction could significantly restrain ICAM-1 expression (P lt;0.05). Conclusion Daotan Decoction could restrain ICAM-1 expression induced by TNF-@ in different phase. Keywords:: Daotan Decoction, cerebrovascular endothelial cell, ICAM-1, rat Monocyte adhesion to the endothelium in vascular endothelial migration and under the bubble of early atherosclerosis is the pathological process [1]. Intercellular adhesion molecule -1 (ICAM-1) have wo