Deep slow wave sleep in the rat insulin regulation of the role of.docVIP

 PAGE \* MERGEFORMAT 12 Deep slow wave sleep in the rat insulin regulation of the role of Of: Zhang Jin Li Chunhua Wang Kai Zhang Yin beans Wanglie Cheng Zhao line movement [Abstract] Objective To investigate insulin on sleep, especially deep slow wave sleep. Methods SD rat hippocampal CA1 area dose injection of different reagents and divided into control group, 0.05 IU insulin, 0.1 IU insulin group and 0.2 IU insulin, the use of stereotaxic positioning nuclei intubation, and polysomnography microinjection tracings hippocampal CA1 area observed by microinjection of insulin on sleep-wake cycle. hippocampal CA1 microinjection of the results of 0.05 IU of insulin on large rat sleep-wake cycle and no significant effect on the depth of sleep. microinjection of 0.1 IU of insulin, the awakening time is reduced, total sleep time increased, compared with the control group, slow wave sleep time increased 18.1% (P lt;0.05, and is mainly shallow increase in slow wave sleep ingredients 22.0% (P lt;0.01. microinjection of 0.2 IU of insulin, the awakening time is reduced, increasing the total sleep time, sleep better, compared with the control group, slow wave sleep time increased 29.8% (P lt;0.01, which light slow wave sleep time increased 21.6% (P lt;0.01, deep slow wave sleep time increased 53.2% (P lt;0.05. Conclusions of insulin in the hippocampus involved in the regulation of sleep and have sleep promoting effects of insulin on the depth of sleep, and injected dose were positively correlated. [Keywords:] insulin, hippocampus, sleep, polysomnography tracings surgery Polysomnographic study found that the elderly, primary insomnia and sleep disorders caused by mental disorders, their characteristics were shown to reduce the time for the deep slow-wave sleep, or even absent, showing that deep slow wave sleep in normal sleep and sleep disorders play a an extremely important role. Valatx, etc. (1) reported that the expression of human insulin gene in transgenic mi