Determination of serum triglycerides.docVIP

 PAGE \* MERGEFORMAT 7 Determination of serum triglycerides Abstract: The serum triglyceride / triglyceride (TG is an important indicator of clinical determination of blood routine, especially with its induced atherosclerosis (AS-depth study of the role, TG as an independent coronary heart disease Risk factors and more attention [1 ~ 3]. But now the serum TG and its clinical application there are still many problems, such as biological variation, the impact on the determination of free glycerol, the determination of standardized systems are imperfect and so on. This is only TG biochemistry, determination and standardization of clinical significance and other aspects of recent developments are briefly described. Keywords: Clinical significance of determination of serum triglycerides TG metabolism can be divided into exogenous and endogenous two ways. Extrinsic pathway of food in the hydrolysis of TG in the small intestine into fatty acids and glycerol ester, ester into the cells after the intestinal absorption, and then synthesis of TG with other lipids to form CM, through the lymphatic system into the blood. CM of TG in the lipoprotein lipase (LPL hydrolysis under the action of glycerol and free fatty acids (FFA, by the cell to use or storage. fat diet after 3 ~ 6h, CM-related blood TG peak absorption rate of fat because of dietary fat composition and individual differences and different. endogenous metabolic pathways of hydrolysis products that CM-CM remnant in the form of receptor-mediated uptake by the liver, its Synthesis of derivatives and some new components of VLDL. hydrolyzed with similar CM, VLDL secreted into the blood after LPL hydrolysis of remnant, some of which directly liver absorption, and partly to hydrolysis of intermediate density lipoprotein (IDL, the last generation LDL.VLDL synthesis and hydrolysis of regulation by many factors, including substrate utilization, hormone status, hydrolytic enzyme activity and specific activity of