Different doses of mifepristone treatment on menopausal DUB efficacy.docVIP

 PAGE \* MERGEFORMAT 7 Different doses of mifepristone treatment on menopausal DUB efficacy [Abstract] Objective To investigate the treatment of menopause taking different doses of mifepristone clinical efficacy in patients with dysfunctional uterine bleeding and to investigate its effect on endocrine function. Methods May 2005 -2010 in our hospital in July confirmed 87 cases of patients with climacteric dysfunctional uterine bleeding randomly divided into 3 groups, observed a group of 30 patients taking mifepristone 6.25mg / d, 2, 30 patients observed taking mifepristone 12.5mg / d, both groups started at curettage after medication, treatment 3 months; the control group of 27 patients taking medroxyprogesterone 8mg / d, on the 15th day of menstruation, and even served on the 10th, for 3 months. Comparison of using different doses of mifepristone in the efficacy of treatment of menopausal dysfunctional uterine bleeding, side effects. Results 3 patients symptoms were different degrees of ease, observing a group and observe the 2 groups were 80% cure rate and 86.6%, significantly higher than 22.2%; observation group 1 and group 2 the recurrence rate observed 6.7% and 3.3%, significantly lower than the control group 25.9%. observed a group of 36.7% incidence of side effects was significantly lower than the observed 56.7% in group 2. Conclusion serving low dose of mifepristone can induce menopause DUB patients with amenorrhea, menstruation or reduction rules, side effects is small, effective safe and effective. [Keywords:] mifepristone; different doses; menopause DUB Menopausal uterine bleeding is due to the gradual degradation of menopausal women, ovarian function, and the remaining follicles of the pituitary gonadotropin response to low, and thus lose the normal cyclical changes in female hormone appears irregular vaginal bleeding. Common clinical symptoms of irregular uterine bleeding, menstrual cycle disorders, menstrual period of varying lengths, amou