Different pretreatment methods Stopper human serum albumin can be seen the impact of foreign matter detection rates.docVIP

 PAGE \* MERGEFORMAT 15 Different pretreatment methods Stopper human serum albumin can be seen the impact of foreign matter detection rates 【Abstract】 Objective To compare the human serum albumin-packing with rubber plug different treatment methods on visible foreign matter detection rates. Method using the French STELMI Dingjijiaose, use the first method 0.2μm membrane filter wash water for injection, the second method stopper 121 ℃ Humidity 30min after sterilization using 0.2μm membrane filtration countercurrent wash water for injection; third method Stopper 121 ℃ Humidity 30min after sterilization using 0.2μm membrane filtration water for injection, counter-current washing, countercurrent washing 0.2μm membrane filters used in compressed air at the same time oscillations, comparing three different methods of pretreatment serum albumin semi-packing posterity to conduct visual inspection to compare the impact of visible foreign matter detection rate. The results are not clean rubber plug is not used directly for human serum albumin-packing. The first method is visible foreign matter detection rate of 2.8%; the second method shows a detection rate of 1.8% foreign matter; the use of a third method of visible foreign matter detection rate of 1.1%. Conclusion human serum albumin-packing should be carried out with the stopper prior to use pre-treatment, different treatment methods on human serum albumin-packing can be seen after the foreign matter detection rate of greater impact. Keywords: human serum albumin; Dingjijiaose; membrane filtration; injection water; visible foreign matter inspection Human serum albumin (HAS) due to a maintenance of intravascular colloid osmotic pressure, combined with the body and delivered a variety of fatty acids, hormones, ions and a variety of drugs important biological functions, has been widely used in a variety of low albumin disease or traumatic shock [1], as the plasma protein industry, during World