Docetaxel combined with cisplatin in human osteosarcoma and the role of chemotherapy.docVIP

 PAGE \* MERGEFORMAT 33 Docetaxel combined with cisplatin in human osteosarcoma and the role of chemotherapy Abstract [Objective] To investigate docetaxel combined with cisplatin on human osteosarcoma cell growth inhibition and the role of chemotherapy in osteosarcoma. [Methods] cell count, morphology, flow cytometry to detect and observation, respectively, and combined with docetaxel and cisplatin in human osteosarcoma cell line growth inhibition; established animal model of nude mice bearing human osteosarcoma, respectively, and joint Application of docetaxel and cisplatin for treatment of their and the establishment of blank control. Observe the tumor growth and pathological indicators. [Results] docetaxel and cisplatin combination therapy, respectively, are within a certain range of osteosarcoma cells significantly inhibited the proliferation and induce apoptosis, and the role of combined treatment group was stronger than single treatment group, inhibition rate ≥ 59.34% (P lt;0.05;), apoptosis rate of 18.31% (P lt;0.01). Docetaxel and cisplatin alone could inhibit tumor growth of osteosarcoma, tumor inhibition index were 84.16%, 78.53%; between the two was more effective when combined, tumor inhibition index of 96.78%. [Conclusion] docetaxel and cisplatin combination therapy compared with individual drugs on osteosarcoma cell proliferation inhibition stronger chemotherapy in osteosarcoma stronger role. Keywords: Docetaxel; osteosarcoma; nude mice; apoptosis Osteosarcoma is the most common primary bone cancer, and good in adolescents. Docetaxel (docetaxel, TXT) is a novel broad-spectrum anticancer drugs, can cure a variety of advanced cancers such as lung, stomach cancer and ovarian cancer, such as 〔1,2〕 but in the treatment of osteosarcoma reported in the literature few . In this study, in vivo, in vitro study of two multi-West Pacific yew on human osteosarcoma cell line HOS-8603 and the proliferation inhibitory effect in nude mic