Dopamine transporter in Parkinsons disease and drug intervention of abnormal.docVIP

 PAGE \* MERGEFORMAT 17 Dopamine transporter in Parkinson’s disease and drug intervention of abnormal [Abstract] dopamine transporter (Dopamine transporter, DAT) is located in the dopaminergic neurons presynaptic dopamine uptake sites again, controlling the concentration of dopamine in the synaptic cleft; how much it can indirectly reflect the substantia nigra - striated dopaminergic pathway and function of the number of neurons, it is considered the brain DAT dopaminergic neurons markers. DAT in Parkinson’s disease (parkinson’s disease, PD) of the occurrence and development play an important role. article from DAT The structure, distribution, function and transport regulation, and the relationship between PD and drug intervention were reviewed. [Keywords:] Parkinson’s disease; dopamine transporter; Summary Parkinson’s disease (parkinson’s disease, PD) is a kind of resting tremor, bradykinesia, increased muscle tone and posture balance disorders as a typical clinical syndrome of slowly progressive neurodegenerative disease, mainly from the Black brain quality of pars compacta dopamine (dopamine, DA) neurodegeneration caused by the imbalance of DA and acetylcholine. At present, PD pathogenesis has not yet fully elucidated, recent studies have shown that, DA can neurotoxin MPP + and other substances into the nerve through the DAT element, and single photon emission computed tomography (SPECT) in early PD patients showed significantly lower levels of DAT. dopamine transporter (dopamine transporter, DAT) located in the central terminals of dopaminergic neurons, is a membrane protein. depth of DAT extensive research will help clarify the etiology of PD, early diagnosis and prevention of drug progress. 1 DAT structure DAT is a membrane protein, belongs to Na + / Cl-dependent transporter proteins, DAT contains about 620 amino acids, the molecular weight of about 70 KD. With 12 transmembrane functional areas, mainly by the transmembrane region of 20 to 2