Docetaxel combined with fluorouracil and cisplatin for treatment of advanced gastric cancer.docVIP

 PAGE \* MERGEFORMAT 5 Docetaxel combined with fluorouracil and cisplatin for treatment of advanced gastric cancer Author: Qian Li, Mao Guo Xin, ups and downs, Li Mei [Abstract] Objective To observe the domestic docetaxel (TAT) jointly Leucovorin / 5 - fluorouracil (CF / 5  Fu) and cisplatin (DDP) treatment of advanced gastric cancer, and adverse reactions. Methods 41 patients with advanced gastric cancer patients receiving TAT and CF / 5  Fu and DDP combination chemotherapy: TAT75mg/m2, intravenous 1h, d1; CF100mg, intravenous 2h, d1 ~ 5; 5  Fu500mg/m2, 22h continuous static micro-pump drops, d1 ~ 5; DDP25mg/m2, intravenous infusion, d1 ~ 3. 28 days cycle. Treatment of two cycles evaluate the efficacy and adverse reactions. Results 41 patients were available were evaluated. 2 cases of complete remission, partial remission in 23 cases, efficiency 61.0%. The median time to progression 7.5 months, median survival time 10.6 months, one year survival rate was 41.5%. The main adverse reactions were bone marrow suppression, alopecia and peripheral neuritis. Conclusion Domestic docetaxel combined with calcium folinate / 5  fluorouracil and cisplatin for treatment of advanced gastric cancer to alleviate the high rate of toxicity can be tolerated. [Keywords:] Docetaxel; 5  fluorouracil; cis-platinum; gastric cancer Of gastric cancer because of early symptoms of hiding, when the majority of patients already diagnosed with locally advanced or metastasis has occurred. Treatment of poor prognosis with surgery alone, 5-year survival rate of 5% to 15% [1]. Gastric cancer is relatively sensitive to chemotherapy of cancer, current treatment of advanced gastric cancer is a commonly used 5  Fu, DDP-based three-drug combination of drugs, or 4 program [2]. New drugs and new combination chemotherapy in the treatment of advanced gastric cancer has been increased to 65% efficient, and less toxicity [3  6]. Our hospital in May 2003 ~ December 2005 Application of Jia