Double platinum intraperitoneal infusion intravenous chemotherapy for advanced gastric cancer 38 cases.docVIP

 PAGE \* MERGEFORMAT 6 Double platinum intraperitoneal infusion intravenous chemotherapy for advanced gastric cancer 38 cases As the intra-abdominal metastasis and recurrence of gastrointestinal metastasis and the main cause of death in an important way, so in recent years, gastrointestinal cancer, intraperitoneal chemotherapy has become another widely used in clinical treatment and I began to use Division since 1999, intra-abdominal perfusion and radiofrequency hyperthermia treatments of advanced gastric cancer, and achieved satisfactory results, are as follows. Object and method 1.1 The study - June 1999 August 2003 our department treated 76 patients with advanced gastric cancer, 47 males and 29 females, aged 31-76 years, median age 54 years. All cases were confirmed by clinical, radiological (CT, B Chao), biochemical and pathological diagnosis and other methods. admission tumors involving the range: hot filling abdominal lymph node metastasis group, 24 cases of liver metastases in 15 cases, ascites in 10 cases, abdominal lymph node metastasis in the control group, 25 cases of liver metastasis 12 cases, ascites in 9 patients. two sets of clinical data are comparable. 1.2 Heat treatment group were treated with intravenous chemotherapy and filling the abdominal cavity heat sink and radiofrequency hyperthermia, specific programs are: ① intravenous chemotherapy: CF +5- FU + VP-16 program. Leucovorin (CF) 100mg, intravenous infusion of 1 5 days, fluorouracil (5-FU) 500mg, intravenous infusion of 1 to 5 days, etoposide (VP-16) 100mg, intravenous infusion of 1 to 3 days. ② abdominal perfusion and radiofrequency hyperthermia: chemotherapy the first day plus intraperitoneal hyperthermic perfusion, routine abdominal paracentesis, ascites, first exhausted ascites, and then cisplatin (DDP) 40mg-60mg + carboplatin (CBP) 200mg adding 150ml-2000ml normal saline, heated in water bath set to 50 ℃ after the rapid injection of the abdominal cavity, the time