Drug target discovery and validation technology advances.docVIP

 PAGE \* MERGEFORMAT 17 Drug target discovery and validation technology advances [Abstract] drug target discovery and validation is the first step in drug discovery, drug screening and drug targeting is a critical factor in synthesis of one. With genomics, proteomics, bioinformatics, rapid development and RNA interference, phage display and other emerging technologies, drug target discovery and validation technology advances. This paper reviews the level of the gene, transcription, protein levels of drug target discovery and validation of the research progress of technologies and success stories. [Keywords:] drug target; target discovery; target validation Abstract: Drug target discovery and verification is not only the first step of investigation of new drug, but also one of the most important factors in drug screening and directional synthesis. With the fast development of genomics, proteomics, bioinformatics and the advancement of new techniques , such as RNA interference and bacteriophage display, the discovery and verification of drug target is changing with every passing day. In the present paper, the development and successful cases of drug discovery and verification were reviewed. Keywords:: Drug target; Target discovery; Target verification Drug target is to find the basis of the drug in the past few centuries, people largely dependent on the five hundred are known drug targets to drug discovery. Genome research shows that human beings have 3 ~ 40 000 genes and more protein, many proteins is to control human disease potential drug targets, so at least 9 / 10 the drug target protein has not yet been discovered. discover and validate new targets for drugs to elucidate the causes of disease, an important mechanism of drug action meaning, is to produce “blockbuster” drug source of innovation. In recent years, with the genomics, proteomics, bioinformatics, rapid development and RNA interference, phage display and other emerging technologies,