Drug treatment of angina.docVIP

 PAGE \* MERGEFORMAT 10 Drug treatment of angina [Abstract] Angina (Angina Pectoris) is coronary insufficiency, cardiac sharp, temporary ischemia and hypoxia caused by the onset of chest pain or discomfort as the main manifestation of the clinical syndrome. Which is characterized by paroxysmal crushing chest pain sensation, may be associated with other symptoms, pain, mainly located in the back of the sternum, may radiate to left arm anterior Zhixin, often occurs in the labor or emotional, each time the episode 3 ~ 5min, may be a few days time, but also several times a day, rest or after the disappearance of nitrate preparations. the disease more common in men, the majority of patients 40 years of age, fatigue, agitation, and feed cold and rainy weather, such as the common acute circulatory failure incentives. [Keywords:] Drug treatment of angina An anti-platelet agents and angina pectoris Unstable angina is between stable angina and a group of between AMI myocardial ischemia syndrome, although the first month of unstable angina and death AMl earlier occurrence rate decreased significantly, but prognosis remains poor following the year of death or nonfatal MI incidence rate of 10% or higher. pathophysiology of unstable angina mechanism has not yet entirely clear, however, coronary angiography, thrombus formation in unstable pathophysiology of angina pectoris play an important role. unstable angina evolved to the ML usually there is a process of thrombosis, the traditional anti-angina drugs can not provide adequate protection. study found that coronary heart disease ischemic attack people thromboxane (TXA2) increased plasma concentrations of metabolites, TXA2 in human platelet arachidonic acid metabolism of the major epoxide product, which is the strong product of platelet activation and vasoconstriction. aspirin through activation of parts of neighboring acetylation of serine residue irreversible inhibition of this enzyme, while ticlopidine inhibi