Drug-induced liver disease diagnosis and treatment of.docVIP

 PAGE \* MERGEFORMAT 5 Drug-induced liver disease diagnosis and treatment of The liver metabolism of drugs in the body and vital organs, but the drug and its metabolites can also affect the structure and function of the liver, causing liver damage. Drug-induced liver disease is in the drug treatment process in the liver by the drugs themselves, metabolites damage or allergic reactions caused by iatrogenic disease occurred. Hazards, including the liver blood vessel damage, inducing liver cancer and cirrhosis of the liver to promote such [1]. Liver cell degeneration and necrosis caused mainly by the toxic metabolite, namely, the pro-electronic alkylation, arylation and acylation substances and liver cells and life-related molecules (DNA, RNA) covalent binding to liver cells caused by necrosis, but also by the cytochrome P450 enzyme oxidation-reduction reaction of free radicals and cell membrane proteins or non-covalent combination of saturated fatty acids, resulting in lipid peroxidation caused by cell membrane damage, eventually leading to cell death. With the continuous advent of new drugs, particularly non-prescription drugs continue to expand, the patient self-medication and the possibility of arbitrary and high-dose increase in the incidence of drug-induced liver disease has also increased accordingly. The drugs currently in use, it was reported that there were 1000 [2] of multi-drug can produce liver damage in the world of all adverse drug reactions, drug-induced liver disease incidence of 3% to 9% [3], accounting for hospitalized cases of jaundice 2% ~ 5%, accounting for adults ‘acute hepatitis’ 10% of hospitalized patients, accounting for drug-induced liver failure patients with acute liver failure 10% ~ 52% [4]. However, as drug-induced liver disease clinical and pathological changes in the complexity of the clinical manifestations and laboratory tests lack specificity, and easily misdiagnosed [5]. On drug-induced liver disease are the main points of di