Drug-metabolizing enzyme gene polymorphism on the impact of drug action.docVIP

 PAGE \* MERGEFORMAT 12 Drug-metabolizing enzyme gene polymorphism on the impact of drug action [Abstract] drug-metabolizing enzyme gene polymorphism on the impact of drug action drug research is now hot and difficult problems. Drug-metabolizing enzymes, including participation in Phase Ⅰ metabolism of CYP450 cytochrome oxidase superfamily (CYP1A1 / 2,1 B1, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4/5/7), aldehyde dehydrogenase ( ALDH), alcohol dehydrogenase (ADH), dioxo-pyrimidine dehydrogenase (DPD), etc. and participate in phase Ⅱ metabolic N-acetyltransferase (NAT1 / 2), uridine triphosphate glucuronyl-transferase enzyme ( UGT), thiopurine S-methyltransferase (TPMT) and so on. In which cytochrome P450 enzymes are a group of ultra-structure and function-related gene encoding isozyme families to participate in the majority of endogenous substances (such as fatty acids, vitamins, bile acids) and metabolism of exogenous substances (eg drugs) detoxification, the former cancer-causing substances (such as aromatic substances) activation, these enzymes in drug metabolism play an important role. Their polymorphism is caused by drug effects in different key. [Keywords:] drug enzyme gene polymorphism The crowd’s response to drugs between individuals, toxicity, and there is a big difference in treatment effect, resulting in the individual differences for many reasons, such as disease pathology and severity, drug interactions, age, sex, nutritional status, organ function , complications and so on, but genetic factors, namely, drug-metabolizing enzymes, transporters and drug targets (eg receptor) genetic polymorphism is also an important factor. The following focuses on drug-metabolizing enzyme gene polymorphism on the impact of drug action of drugs. The active drug, as exogenous substances, the body first of all to its inactivation, while also promoting its elimination from the body. The main body of drug biotransformation in the liver by the loss of pharmacological a