dsRNA and the interferon and the close link between the transfection of the application between the two.docVIP

 PAGE \* MERGEFORMAT 18 dsRNA and the interferon and the close link between the transfection of the application between the two [Abstract] IFN and dsRNA production of the relevant research has been among the notable progress has been found that there are two kinds of cells, enzymes (PKR, 25AS) are closely related with the production of interferon, but also in the process of interferon-induced, dsRNA chain poly inosine-cytidine acid (Polyinosinic) Poly (I: C) can be double-stranded RNA-dependent protein kinase (PKR) activation specifically. DsRNA and the correlation between interferon is also reflected in a number of cellular regulatory factors and the effects of factors, such as IRFs, Mx protein, Toll-Like receptor mAb and a number of cytokines at the same time, dsRNA induced through IFN born to stimulate the cells to produce apoptosis, if the correlation between the two by cell transfection technology to achieve, can be further explored and examined. [Keywords:] interferon; dsRNA; transfection, apoptosis Correlation and transfection applying betneen dsRNA and interferon [Abstract] The distinct advance have been formed about the correlation rsearch between dsRNA and interferon (IFN), recently it’s found that there are two enzymes in the cell tightly correlating with the production of IFN. And during the production of IFN induction, the polyinosinic polycytidylic Acid, poly (I: C) in the dsRNA chain could be specific activated by double-stranded RNA-dependent protein kinase (PKR). In addition, many cellar regulator and effector also expressed the correlation between IFN and dsRNA, such as interferon regulatory factors (IRFs), mx protein, the mAb of toll-like receptor, and some cytokine.Simultaneously, dsRNA could activate the cell programmed death through the induction of IFN, if the correlation could be realized and communicated by the technology of cell transfection , it would be exploited and researched more deeply and completely. [Keywords:] IFN