Effect of atorvastatin on the infarct zone in rats after myocardial infarction and apoptosis in non-infarcted myocardium and plasma BNP levels.docVIP

 PAGE \* MERGEFORMAT 10 Effect of atorvastatin on the infarct zone in rats after myocardial infarction and apoptosis in non-infarcted myocardium and plasma BNP levels Of: Songxian Jing Yang Ping Wei Qun Zhao Dongming Yang Chunyan [Abstract] Objective Wistar rats through continuous ligation manufacturing anterior descending coronary artery myocardial infarction animal model of atorvastatin on the infarct zone in rats after infarction and apoptosis in non-infarcted myocardium and plasma B-type natriuretic peptide (BNP ) level. Methods Male Wistar 60 rats, randomly selected 8 as the sham group, the other 52 continued through the anterior descending coronary artery ligation rat model, ELISA method to measure serum cardiac troponin T (CTnT) level, will CTnT level greater than 4.00 ng / ml of 31 rats were randomly divided into 2 groups, control group 15, the experimental group 16. sham operation group and normal diet control group, experimental group were given normal diet + atorvastatin (10 mg kg-1 d-1), continue feeding after 5 w measured by ELISA, BNP levels in the blood will flow cytometry method to measure infarct zone and non-infarcted myocardium cell apoptosis. Results After feeding 9 w measured plasma BNP levels: the control group and experimental group than sham operation group (P lt;0.05), the experimental group was significantly lower than the control group (P lt;0.05); flow cytometry method to measure apoptosis in myocytes rate: the experimental group apoptotic myocytes was significantly lower than the control group, experimental group, the apoptosis rate of non-infarct zone compared with the control group; the experimental group and control group of non-infarct area and apoptosis of myocytes was higher than sham operation group (all P lt;0.05). Conclusion atorvastatin can reduce the infarct zone in rats after myocardial infarction and non-infarcted myocardium apoptosis, and decreased plasma BNP levels, to a certain extent, play a role in improvin