Effect of carvedilol on doxorubicin induced cardiomyopathy the impact of oxidative stress in rats.doc

 PAGE \* MERGEFORMAT 16 Effect of carvedilol on doxorubicin induced cardiomyopathy the impact of oxidative stress in rats Of: Yu Jie, Cheng-Hua Wang, Tao Yibin, Yinchun Yang, Nitrogen, Zhang Guohui [Abstract] Objective: To investigate the effects of carvedilol (carvedilol, CVD) of doxorubicin (adriamycin, ADR) induced oxidative stress cardiomyopathy in rats and its possible mechanism. Methods: intraperitoneal injection of doxorubicin established cardiomyopathy rats were randomly divided into carvedilol group and doxorubicin group, n = 10. In another 10 normal rats as control group. carvedilol group given carvedilol daily Los 60 mg / kg, doxorubicin group and the normal control group given the same volume of normal saline daily, 8 weeks. 9th week and hemodynamic cardiac ultrasound testing to measure ventricular collagen content, total antioxidant capacity and C dialdehyde concentration. Results: The carvedilol group and the doxorubicin group, can significantly improve left ventricular ejection fraction (P lt;0.01), reduced myocardial collagen volume fraction (P lt;0.01). and the normal control group ratio, doxorubicin group, the total antioxidant capacity was significantly lower (P lt;0.01), MDA concentration was significantly higher (P lt;0.01), but not with doxorubicin compared carvedilol group had a significant increase total antioxidant capacity (P lt;0.01), significantly reduced malondialdehyde concentration (P lt;0.05). Conclusion: Carvedilol can significantly improve the doxorubicin induced hemodynamic abnormalities and improve cardiac systolic and diastolic function and reverse myocardial remodeling may be related to increased myocardial oxidative stress capacity. [Keywords:] doxorubicin, carvedilol, oxidative stress [Abstract] Objective: To investigate the influence of oxygen stress in rat with adriamycin induced cardiomyopathy, and to intervene with the third generation blocker: carvedilol to explore its possible mechanism. Methods: Male Sp