Effect of rosiglitazone on myocardial hypercholesterolemia adiponectin and TNF levels.docVIP

 PAGE \* MERGEFORMAT 16 Effect of rosiglitazone on myocardial hypercholesterolemia adiponectin and TNF levels Of: Shengzu Long, Huding Bo, Li Ying Juan, Li Yan Zhi, Ren Liqun [Abstract] Objective: To investigate the myocardial hypercholesterolemia adiponectin and TNF @ level changes and their intervention rosiglitazone. METHODS: 28 male Wistar Kyoto rats were divided into normal diet group (Con group, high cholesterol diet group (Cho group, high cholesterol diet + rosiglitazone (Ros group), the morning of rosiglitazone in normal saline orally, 4 mg kg-1 d-1.Ros group adaptive high-cholesterol diet feeding 1 month after drug intervention, for 5 months. with full automatic biochemical analyzer enzymatic serum lipids, enzyme-linked immunosorbent assay cardiac adiponectin and TNF @. Results : Cho group of lipids, myocardial TNF @ level higher than the Con group, myocardial adiponectin levels were significantly lower, rosiglitazone can significantly reduce blood esters, myocardial TNF @ levels, increased myocardial levels of adiponectin. adiponectin and myocardial ester and TNF @ was negatively correlated (r =- 0.636, P lt;0.01. Conclusion: Rosiglitazone significantly reduced by lipid and TNF @ levels, while elevated levels of cardiac adiponectin play a role in myocardial protection. [Keywords:] adiponectin, tumor necrosis factor @, high cholesterol, rosiglitazone, rat [Abstract] Objective: To investigate the effects of rosiglitazone on the levels of myocardial adiponectin and TNF @ in a rat model with experimental hypercholesterolemia.Methods: Hypercholesterolemic rats were induced by a cholesterol rich diet.Twenty eight male Wistar Kyoto rats were randomly allocated into three groups: (1) the control group (Con group), which was fed a regular diet; (2) the cholesterol rich diet group (Cho group), which was fed a cholesterol rich diet; and (3) the rosiglitazone treatment group (Ros group), which was fed a cholesterol rich diet plus rosiglitazone (rosi