Effect of verapamil on ESWL induced kidney injury in rats.docVIP

 PAGE \* MERGEFORMAT 8 Effect of verapamil on ESWL induced kidney injury in rats Of: Jianghua Mao, Guo Min, Zhang Chunyang, Lichen Guang, Zhang Datian [Abstract] Objective To establish a rabbit model of extracorporeal shock wave injuries to investigate verapamil on the role of ESWL induced kidney damage. Methods 24 rabbits were randomly divided into control group and verapamil group, n = 12, to extracorporeal shock wave (12KV 2000 times) injury, injury, respectively, 15 min before intravenous injection of saline and ginseng saponins, measured 24 h after renal hemorrhage under the capsule of tissue density and area of #8203;#8203;hemorrhage and urinary -GT/Cr, IgG / Cr levels and pathological observation. Results verapamil urinary -GT, IgG levels than the control group, compared with the control group, renal hemorrhage organizations verapamil group density and area of #8203;#8203;subcapsular hemorrhage was reduced. pathological observation showed that two groups are different degrees of renal damage. Conclusion Verapamil can reduce kidney damage in rabbits induced by ESWL. [Keywords:] verapamil; extracorporeal shock wave lithotripsy; renal injury Abstract: Objective to study the effect of verapamil on renal damage induced by extracorporeal shock wave lithotripsy (ESWL) in renal injury models of rabbits. Methods 24 rabbits were randomly divided into the verapamil group and the control group, 12 in each group, and they were treated with intravenous injection of verapamil and saline respectively, 15 minutes later, they were given the extracorporeal shock wave lithotripsy. The urinary -GT/Cr, IgG / Cr and the volume of renal hemorrhagic tissue and hemorrhagic area under renal fascia were measured 24 hours after ESWL. Results In the verapamil group, there was a significant decrease in the urinary -GT/Cr, IgG / Cr volume density of renal hemorrhagic tissue and hemorrhagic area under renal fascia compared with the control group after ESWL. We observed rena