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Effects of estrogen on bone ApoE knockout mice and RANKL OPG effects
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Effects of estrogen on bone ApoE knockout mice and RANKL OPG effects
[Abstract] Objective To observe the effect of estrogen on the femur in ovariectomized C57BL/6J mice osteoprotegerin (OPG) and RANKL. Methods Preparation of bilateral oophorectomy osteoporosis (OP) model, 1 w after estrogen group began weekly intraperitoneal injection of estradiol benzoate (EB) 2 times, the model group (E2 group) injected with an equal amount of olive oil .6 w after the application of immunohistochemical method in the femur of mice OPG, RANKL changes . Results There OPG and RANKL in mouse femur there was no significant difference (Pgt; 0.05). Conclusion Estrogen can not increase the ApoE knockout mouse femur in the expression of OPG and RANKL play a role in anti-OP.
[Keywords:] Osteoporosis; estrogen; OPG; ApoE
Osteoporosis (Ostoporosis, OP) has become common in the elderly body bone metabolic diseases, especially common in women after menopause, so estrogen and OP on the related research has become a hot spot. A lot of basic research have confirmed that estrogen Protective effects of hormones, but its mechanism is still unknown (1,2). in recent years with osteoprotegerin (OPG) The discovery of OPG / RANK / RANKL system of concern, domestic and international studies have shown that OPG and RANKL may binding inhibitor of osteoclast (OC) formation and activation of osteoclasts play a role in anti. Another suggestion was that OP may be genetic factors, because genetic factors determine the maximum density of each person, but little research on this area, particularly on the apolipoprotein E (apolipoprotein, ApoE) gene. In this paper, ApoE knockout mice for research, trying to OP from the perspective of the incidence of the genetic mechanism for OP to provide a theoretical basis for drug development.
1 Materials and methods
1.1 The selection of animals and group health, active C57BL/6J ApoE knockout female 20, aged mice 12 w, weighing about 20
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