Effect of carvedilol intervention in patients with chronic heart failure in cardiac function and vascular endothelial function.docVIP

 PAGE \* MERGEFORMAT 5 Effect of carvedilol intervention in patients with chronic heart failure in cardiac function and vascular endothelial function [Abstract] Objective To investigate the effects of carvedilol on cardiac function in patients with chronic heart failure and vascular endothelial function of the intervention effect. Methods with chronic heart failure (cardiac function Ⅲ ~ Ⅳ ) 60 patients were randomly divided into carvedilol group and the conventional group. The conventional group to be digitalis, diuretics, converting enzyme inhibitors and aldosterone antagonist combination therapy; carvedilol group on the basis of conventional therapy plus carvedilol. Two groups were on treatment before and after treatment in June to evaluate the cardiac function, echocardiography, left ventricular function parameters, vascular ultrasound detection of brachial artery endothelial function. Results in June when the two groups were significantly improved cardiac function, no statistically significant difference between two groups. Carvedilol group can significantly improve vascular endothelial function (P amp;lt;0.01), while the conventional group improvement was not obvious. Conclusions Carvedilol can be effective treatment for heart failure, improve vascular endothelial function. [Keywords:] propanol amine card azole ventricular function in congestive heart failure vascular endothelial vasodilation Vascular endothelial dysfunction in patients with chronic heart failure (CHF) the occurrence and development plays an important role in improving endothelial dysfunction has increasingly become a new target for CHF therapy. 3rd generation non-selective β -blocker carvedilol because of its wide range of cardiovascular protective effect has been widely used in clinical treatment of CHF, and evidence-based medicine has achieved good results [1]. Usually the clinical application of the brachial artery reactive hyperemia test reflects the endothelium-dependent vasodila