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Effects of berberine on diabetic rat aorta endothelial injury
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Effects of berberine on diabetic rat aorta endothelial injury
Study: Shiraiwa Jie Wang Zhuo Wang Chunmei Wang Chunyan Xu Jiaqi Chen
[Abstract] Objective berberine on vascular endothelial function in type 2 diabetic injury. Methods small dose of intraperitoneal injection of streptozotocin method of high fat diet type 2 diabetic rat model. The model animals randomly divided into model group, berberine group, a separate control group and normal berberine group. 8 w treatment group after oral administration, to do glucose tolerance test, animals were detected by fasting plasma glucose in serum (FPG ), total cholesterol (TC), triglyceride (TG), fasting serum insulin (FINS) level of serum nitric oxide (NO) and superoxide dismutase (SOD) levels, immunohistochemistry was used to detect endothelial nitric oxide synthase (eNOS expression. Results Compared with model group, berberine treatment group FPG, TC, TG levels were significantly decreased (P lt;0.05), serum insulin levels have increased, but no significant difference (Pgt; 0.05, berberine can improve insulin sensitivity in diabetic rats, while increasing the rats by intraperitoneal injection of glucose tolerance, insulin resistance (all P lt;0.01), berberine can significantly reduce diabetes of serum NO content and increase SOD levels (P lt;0.05, P lt;0.01), thoracic aorta significantly decreased eNOS protein expression (P lt;0.05), while the normal rats were given berberine treatment, these indicators are not significant change. Conclusion Berberine type 2 vascular endothelial injury in diabetic rats has significant protective effect.
[Keywords:] berberine, diabetes, vascular endothelial, nitric oxide, eNOS
[Abstract] Objective To observe the effect of berberine on serum NO level, SOD activity and eNOS expressions of aorta in type 2 diabetic rats induced by high fat diet plus STZ and explore the mechanism underlying protective effect of berberine on endothelial dysfunction. Met
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