Effects of icariin on cysteine stimulated the proliferation of vascular smooth muscle cells.docVIP

 PAGE \* MERGEFORMAT 12 Effects of icariin on cysteine stimulated the proliferation of vascular smooth muscle cells Of: Ma Yijun, Wei Yan, Zhu Jingyuan, Xiao-Juan Zhang [Abstract] Objective icariin on cysteine #8203;#8203;stimulated rabbit vascular smooth muscle cell proliferation, as of icariin lowering blood pressure, prevent atherosclerosis and its mechanism and provide experimental basis for efficacy. Methods rabbit vascular smooth muscle cell proliferation model group were given different doses of icariin treatment determined by MTT OD value of cells in each group, analyzed by flow cytometry cell cycle. and TUNEL method were observed with apoptotic cells, flow cytometry Detection of cell apoptosis. Results cysteine #8203;#8203;could significantly promote the proliferation of VSMC (P lt;0.05), and icariin on proliferation of smooth muscle cells stimulated cysteine #8203;#8203;significantly inhibited (P lt;0.05). prostitution hopanes glycosides affected sheep smooth muscle cell proliferation and cell cycle, the S phase cells decreased. icariin on proliferation of rabbit vascular smooth muscle cells and promote apoptosis, with the drug concentration increased, the apoptosis rate increased. Conclusion Effects of icariin on proliferation of rabbit vascular smooth muscle cells inhibited the growth and induce apoptosis in the treatment of cardiovascular disease has important research value. [Keywords:] icariin; vascular smooth muscle cells; proliferation; apoptosis Atherosclerosis (atherosclerosis, As) is the pathological basis of many cardiovascular diseases, the incidence of vascular smooth muscle cells (vascularsmoothmusclecell, VSMC) proliferation has always been dominant. In recent years, some scholars have proposed the use of drugs to promote VSMC withered death to prevent their excessive proliferation, thereby treating atherosclerosis of new ideas [1 ~ 3]. whether the regulation of VSMC by drugs of programmed cell death, will be the treatment o