Elderly patients with primary biliary cirrhosis of.docVIP

 PAGE \* MERGEFORMAT 12 Elderly patients with primary biliary cirrhosis of Of: Zhang Weimin Zhou Shufen Shu-industry [Keywords:] liver cirrhosis; biliary; elderly Primary biliary cirrhosis (PBC) is a chronic autoimmune-mediated cholestatic liver disease. Western countries the prevalence is higher. Of the low incidence rate than the West. The disease diagnosed according to clinical manifestations and autoantibodies testing. in recent years due to increased awareness of the disease, and some autoantibodies in the beginning of application of experimental methods, detection of cases has increased. To investigate the antibodies in the presence of liver disease status and significance, choose 3 000 cases of liver function have a clear damage in patients with liver disease were detected in 116 cases of PBC patients. According to the patients were divided into two groups (elderly group and non-elderly group) for analysis. 1 Materials and methods 1.1 The subjects were 116 patients with PBC, Department of Hepatology from hospital inpatient, outpatient, and consultation of patients outside the hospital, have a detailed medical history records and the results of a more complete inspection report, all patients were followed up. Elderly group of 50 patients aged 60 to 71 (mean 65 + -4.6) years, male 9 and female 41 cases; 66 cases of non-elderly group, aged 31 to 59 (mean 49 + -7.8) years, male 6, female 60 cases. All patients were non A-G hepatitis, excluding EB virus and cytomegalovirus infection, there is unexplained abnormal serum transaminases, alkaline phosphatase, glutamyl transferase, bilirubin significantly increased and some signs of liver disease . Object Selection criteria: intrahepatic cholestasis of clinical and biochemical characteristics; imaging exclude biliary obstruction; immunological tests of anti-mitochondrial antibody / anti-mitochondrial antibody M2 subtype (AMA / AMA M2) positive, anti-nuclear point antibody (Sp100 antibody) or ant