Endometrial integrins and infertility.docVIP

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Endometrial integrins and infertility

 PAGE \* MERGEFORMAT 10 Endometrial integrins and infertility Keywords:: infertility integrin-implantation endometrium Infertility is one of common gynecological diseases, according to statistics the incidence of foreign couples of reproductive age 10% to 25%, with the wide range of assisted reproductive technology, development and continuous improvement, its treatment success rate continues to increase. The puzzling is that there are nearly 15% to 20% of infertile couples eventually could not find the exact cause of [1,2], but also as a last resort in vitro fertilization treatment of infertility - embryo transfer (IVF-ET) their pregnancy success rate of only 12% ~ 35%, and increased with age, while the decline in [3]. Another study found that [4], the crowd, 22% of pregnancies in the clinical diagnosis has not occurred before the abortion. These phenomena caused people to infertility in patients with implantation defects in more and more attention. Endometrium during implantation embryos and synchronization of development and mutual cooperation is very important, in which endometrial receptivity is a Key factor, has naturally become a research hotspot. As in recent years, the cell adhesion molecules (cell adhesion moleculars, CAMs), in particular, is one of the integrin (Integrins, also known as integrin protein) continuously in-depth study and to continue reporting integrin expression in female reproductive system of research results, so that People of such molecules in implantation and its relationship with the role of endometrial receptivity interested in the relationship between research, research in this area attempt to reveal some of the pathogenesis of infertility. This paper reviews the recent research in this area reported in the literature results, and summarized below. First, the molecular biology characteristics of integrin Integrin molecule is a group by a variety of trans-membrane glycoprotein receptor composed of the family and its molecular

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