Endometrial stromal sarcoma specific markers and clinicopathological analysis.docVIP

Endometrial stromal sarcoma specific markers and clinicopathological analysis.doc

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Endometrial stromal sarcoma specific markers and clinicopathological analysis

 PAGE \* MERGEFORMAT 12 Endometrial stromal sarcoma specific markers and clinicopathological analysis Of: Huang Shiyong Huang Chuansheng Liang Yunlong [Abstract] Objective: To investigate the endometrial stromal sarcoma (ESS) in the specific markers of estrogen receptor (ER), progesterone receptor (PR), epidermal growth factor receptor (EGFR), desmin (desmin) , CD10, CD44 expression, and analysis of clinical and pathological features of ESS. Methods: 2000 ~ 2009 ESS 32 patients admitted to our hospital patients, by immunohistochemical staining (SP method) detected ER, PR, EGFR, desmin, CD10 and CD44 expression in the ESS and in its pathological features were observed. In another 30 cases of uterine fibroids as controls. Results: ESS, mostly single, tumors similar to the proliferative phase endometrial stromal cells, tumor cells were round, oval, spindle-shaped, with intensive. EGFR in the ESS, and uterine fibroids in the rate of positive expression was no significant difference (Pgt; 0.05), ER, PR, desmin, CD10, CD44 and uterine smooth muscle in the ESS The positive expression rate of tumors significantly (P lt;0.05 or P lt;0.01). Conclusion: The diagnosis of ESS should be combined with its clinical and pathological features, CD10 can be used as diagnostic indicators of specific ESS, CD44 can be aided diagnosis ESS. [Keywords:] endometrial stromal sarcoma; specific markers; pathological analysis [Abstract] Objective: To investigate the expressions of specific markers estrogen receptor (ER), progesterone receptor (PR), epidermal growth factor receptor (EGFR), desmin, CD10 and CD44 in endometrial stromal scarcoma (ESS), and analyze the clinical pathologic features of ESS. Methods: A total of 32 cases of patients with ESS from 2000 to 2009 in our hospital were selected, and the expressions of ER, PR, EGFR, desmin, CD10 and CD44 in ESS were detected by using immunohistochemical SP assay, and its pathologic features were observed under microscope.

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