Endothelial lipase and blood lipids and coronary heart disease.docVIP

 PAGE \* MERGEFORMAT 26 Endothelial lipase and blood lipids and coronary heart disease [Abstract] Endothelial lipase is a lipase found in 1999, a new member of the family, is the expression of vascular endothelial cell gene product for the phospholipase activity main involved in the metabolism of high density lipoprotein and its gene polymorphism related to high density lipid protein cholesterol levels, and in the promotion of atherosclerosis and coronary heart disease incidence, play an important role in the development of a clear mechanism of action for the prevention and treatment of atherosclerosis and coronary heart disease to provide a new way. [Keywords:] Endothelial lipase; high density lipoprotein; gene polymorphism; lipid; coronary heart disease Risk factor for coronary heart disease is a multi-disease, epidemiological studies have confirmed that coronary heart disease risk factors were age, gender, dyslipidemia, hypertension, smoking and diabetes, in which high-density lipoprotein cholesterol (HDL-C) levels is an important factor can not be ignored, it atherosclerotic disease occurrence and development of a negative correlation, low HDL-C levels have been shown to be independent risk factors for coronary heart disease [1,2]. endothelial lipase ( endothelial lipase, EL) was discovered in 1999, a new lipase family member, a growing number of studies have shown that EL is a key enzyme regulating HDL metabolism, EL affects lipoprotein metabolism and atherosclerosis and coronary heart disease, closely related to the development process [3,4]. 1, the biological characteristics of endothelial lipase EL was in 1999 by two different researchers using different methods were found. One group is the Hirata et al [5], the difference in the use of suppression subtractive hybridization technique of vascular endothelial cell formation of genetic characteristics, in the cultured human umbilical vein endothelial cells for the first time cloned EL. In th