Endothelial cells by regulating the function of PPAR on the formation of atherosclerosis protection.docVIP

 PAGE \* MERGEFORMAT 16 Endothelial cells by regulating the function of PPAR on the formation of atherosclerosis protection [Keywords:] peroxisome proliferator-activated receptor, atherosclerosis, vascular endothelial cells Atherosclerosis (AS) morbidity and mortality in various diseases in China and ranks first in the world. From Ross et al (1) of the “damage response theory”, the now generally accepted incidence of AS is due to vascular endothelial cells and smooth muscle cells subject to various risk factors such as viruses, mechanical damage, such as immune complex injury, the local blood vessels to produce a chronic inflammatory proliferative reaction excessive. inflammatory response throughout the occurrence and development of the entire process. The study confirmed previous (1) in plaques in peroxisome proliferator-activated receptors (PPARs) high expression, suggesting that PPARs and closely linked to the development of AS. peroxisomes (peroxisome) is a subcellular structure of the body, Its functions include removal of molecular oxygen and hydrogen peroxide, and with glycolipids, cholesterol, bile acid synthesis and fatty acid peroxidation. a series of natural or synthetic chemical substances can stimulate the proliferation of peroxisomes, called off peroxidase proliferator (PP), Issemann, etc. (2) PP was first reported to activate a receptor, which mediated a series of mouse liver peroxisome proliferation-related genes and opening up, and the lack of the subject the performance of the mouse body is not peroxisome proliferation, these receptors and thus was named PPARs. study (3), PPARs activation can not only improve diabetes, hypertension and obesity, including insulin resistance syndrome but also directly on the vessel wall, slowing the process. PPARs will this review the structure, function, and endothelial cells associated with the research progress briefly. 1 PPAR structure and tissue distribution PPARs of the structure includes six d