Etiology of gestational diabetes.docVIP

 PAGE \* MERGEFORMAT 16 Etiology of gestational diabetes [Keywords:] diabetes mellitus, pregnancy; multifactorial inheritance Gestational diabetes (gestational diabetes mellitus, GDM) refers to non-diabetic before pregnancy and impaired glucose tolerance in pregnancy or the first occurrence of diabetes or impaired glucose tolerance found, GDM does not include the known diabetes before pregnancy. GDM with postprandial blood glucose significantly, fasting blood glucose is low, easy to characteristics of renal glucosuria, usually occurs in late pregnancy, and may also combined with other types of diabetes [1]. normal during pregnancy, the main metabolic change is the increase in insulin resistance caused by decomposition of glucose body showed decreased insulin sensitivity. Normal pregnancy is not caused by decreased insulin sensitivity caused by GDM, only in the secretion of insulin was impaired, can together lead to the formation of GDM. If defective pancreatic cell function, fasting and postprandial blood glucose levels, produce glucose toxicity of pancreatic cells that regulate muscle glucose - glucose conversion system in response to disturbance. At present the exact etiology of GDM is not clear, with a variety of factors, now its causes are reviewed. 1 Genetic factors GDM can be called early onset of clinical type 2 diabetes, there are genetic factors in common, if family history of DM, or DM high race, the incidence rate. Occur in patients with gestational diabetes, type 2 diabetes in the future risk of significant (but has nothing to do with type 1 diabetes). GDM, some people think that the gene causing type 2 diabetes and genetic causes may be related to each other. study found that family history of diabetes, some of the high incidence of diabetes, GDM race may be genetic susceptibility factors, and a GDM while some genes may be involved in susceptibility to type 2 diabetes. African-American women, family history of diabetes, women in Latin A