Essential hypertension in patients with carotid artery intima-media thickness and vascular endothelial function and intervention studies related.docVIP

 PAGE \* MERGEFORMAT 6 Essential hypertension in patients with carotid artery intima-media thickness and vascular endothelial function and intervention studies related [Abstract] carotid artery intima-media thickness (IMT) and vascular endothelial function (EDD) can be used as monitoring the occurrence and development of atherosclerosis an important indicator of an early active intervention has important clinical significance. [Keywords:] essential hypertension endothelial function of carotid artery ultrasound Fosinopril In this study, high-frequency ultrasound examination in patients with hypertension research carotid intima-media thickness and brachial artery endothelium-dependent relaxation function relationships and to observe the fosinopril Ultrasonographic changes before and after treatment, the evaluation of fosinopril on the artery reversal of atherosclerosis. An object and methods 1.1 Object Selection 100 patients with essential hypertension, in order to Laiwu City People’s Hospital in-patient and outpatient, 58 males and 42 female, mean age (61.42 ± 11.6) years of age; election checkup for 100 cases of healthy control group, male and 62 cases, female 38 cases, average age (60.82 ± 12.5) years of age. To exclude diabetes, hyperlipidemia, liver and kidney dysfunction, and the ACEI contraindication. 1.2 Methods 200 cases were selected using high-frequency ultrasound measurement of carotid IMT and brachial artery EDD, to explore its clinical significance and relevance. The group of 100 cases of hypertension were randomly divided into A, B groups, A group for the control group, oral anti-platelet drugs aspirin and diuretics; B group for the treatment group, on the basis of the above-mentioned pharmaceutical treatment every day 6:00 taking fosinopril 10-20mg, taken continuously for 12 months. 6,12 before treatment and treatment of the end of a line of echocardiography. Instruments used Acuson128xp/10 mode color Doppler ultrasonic diagnostic apparat