Erigeron an effective component of calcium antagonistic effect of.docVIP

 PAGE \* MERGEFORMAT 11 Erigeron an effective component of calcium antagonistic effect of [Abstract] Objective To investigate the effective components of Erigeron calcium antagonistic activity. Methods 45Ca transmembrane influx measurement techniques with rabbit intestinal muscle in vitro experiments, observation of Erigeron in the water extract and calcium antagonistic activity of flavonoids. The results of measurement of 45Ca transmembrane influx experiments, with the blank control group Erigeron flavonoids (0.25,1.0 g * L-1) have shown the role of inhibiting calcium influx (P amp;lt;0.05, P amp;lt;0.01), aqueous extract concentration of 1.0 g * L-1 Shi role of non-calcium antagonist rather to promote calcium influx. Rabbit intestinal muscle in vitro experiments, compared with the blank control group water extract group (1.0 g * L-1) frequency, the total flavonoid group (1,0.5 g * L-1) the frequency and tension were significantly inhibited (P amp;lt;0.05). Conclusion Erigeron flavonoids obvious calcium antagonistic effect, while its water extract of calcium antagonism has yet to be confirmed by further studies. [Keywords:] Erigeron; the effective components; calcium antagonism; 45Ca Abstract: Objective To investigate the Ca2 antagonistic effect of active components from Erigeron breviscapus.Methods By 45Ca transmembrane influx method, observed the effect on voltage-dependent Ca2 channel (VDC) in rat aorta about aqueous extract and the flavonoids.Moreover, by duodenum of rabbits in vitro, observed the effect about aqueous extract and the flavonoids on the shrink of intestines, which was excited by Ca2. Results Compared with blank control group, the flavonoids (0.25,1 g * L-1) showed a significant inhibition of Ca2 influx (P amp;lt;0.05, P amp;lt;0.01), but aqueous extract (1g * L-1) promoted Ca2 influx (P amp;lt;0.01). Moreover, aqueous extract (1g * L-1) could reduce the frequency of intestines shrink only, the flavonoids (0.5,1 g * L-1) could re