Eosinophilic esophagitis diagnosis and treatment of.docVIP

 PAGE \* MERGEFORMAT 14 Eosinophilic esophagitis diagnosis and treatment of [Keywords:] Eosinophilic esophagitis Eosinophilic esophagitis (Eosinophilic Esophagitis, EoE) is a fresh wall eosinophil infiltration characterized by inflammatory disease, usually manifested dysphagia, postprandial nausea, vomiting, abdominal pain and diarrhea, adult body weight may appear decline in growth in infants may present obstacles. Closely related to the disease and allergy, some people even EoE called ‘esophagus asthma’. Microscopic examination shows characteristic pathologic eosinophilic infiltration performance. Over the past decade, EoE prevalence upward trend, mainly observed in the incidence of children, while adult patients with EoE also increased significantly. Sweden, a group of adults without any clinical indications for endoscopic biopsy findings in a study, EoE prevalence rate as high as 4.8% [1]. There is currently a lack of domestic large-scale clinical studies, inadequate attention to this disease, which often misdiagnosed and the delay in clinical treatment. 1 EoE etiology and pathogenesis of EoE The exact cause is unclear, it is generally considered by the Joint IgE and non-IgE-mediated food allergy, in which a non-IgE reaction to dominate. Many cells (such as T lymphocytes, macrophages and eosinophils, etc.) and cytokines (eg IL  5, IL  13, ET  1, ET  3, etc.) involved in the reaction. A number of studies confirm that food allergy was originally strictly to avoid contact with an effective way to solve the EoE. Kelly et al [2] on 10 patients with chronic gastroesophageal reflux symptoms, poor efficacy of drugs and surgical treatment of patients with 17 weeks of strict amino acid elemental diet therapy, and found an average of 3 weeks after symptoms have improved to varying degrees ( symptoms disappeared in 8 cases, 2 cases improved), all cases of pathological changes of eosinophilic inflammation were significantly improved. But the resumption