Evodia extract inhibits monocrotaline induced right ventricular hypertrophy.docVIP

 PAGE \* MERGEFORMAT 8 Evodia extract inhibits monocrotaline induced right ventricular hypertrophy Study: High Double Wing Ho Na, Wu Qin, Sun Ansheng [Abstract] Objective To observe Evodia Extract (evodiae, EV on monocrotaline (monocrotaline, MCT) induced right ventricular hypertrophy and to explore its possible mechanism. Methods Male Wistar rats and MCT 60 mg / kg, right ventricular hypertrophy in the rat model. intragastric EV 18 d, measured right ventricular systolic pressure, right ventricular hypertrophy index, lung weight / body weight, lung tissue HE. were observed morphological changes in small pulmonary arteries was observed in EV rats. Results after MCT injection, rats 18 d, ventricular systolic pressure, right ventricular hypertrophy index was significantly increased (P lt;0.01, pulmonary artery smooth muscle thickening, stenosis. intragastric administration of EV 50 ~ 200 mg 18 d, right ventricular systolic pressure, right ventricular hypertrophy index of lung weight / body weight decreased significantly (P lt;0.05, significantly reduced pulmonary arterial remodeling induced by MCT. Conclusion MCT EV on the right ventricular hypertrophy induced by obvious preventive effect, the effect and to reduce pulmonary artery reconstruction, reduce pulmonary artery pressure. [Keywords:] Evodia extract, right ventricular hypertrophy, monocrotaline, in rats Ventricular hypertrophy caused by a variety of reasons, a high incidence of major hazards. The existing number of scholars believe that even in early ventricular hypertrophy is a harmful reaction [1], inhibit the occurrence and development of ventricular hypertrophy is one of prevention and treatment of heart failure important measures. medicine Evodia Euodia rutaecarpa (J uss) Benth Rutaceae Evodia is nearly mature, dry fruit, a wide range of pharmacological effects [2], recently our laboratory confirmed that the extract inhibits vascular smooth muscle cell proliferation, we further investigated