Excel-based pharmacokinetic data analysis program - PKSlover 1.0 of the preparation and validation.docVIP

 PAGE \* MERGEFORMAT 13 Excel-based pharmacokinetic data analysis program - PKSlover 1.0 of the preparation and validation [Keywords:] pharmacokinetics;,, data analysis;,, Excel;,, PKSolver, 1.0,,,, Abstract: Objective: To prepare and verify that the pharmacokinetics of Excel-based data analysis, common procedures. Methods: Using Excel’s built-in functions, Solver tools, and VBA language, including the preparation of intravenous injection of a compartment, two compartment intravenous, intravenous 3 AV, non-vascular one room, non-vascular one room (with delay) of non-vascular two rooms, two rooms of non-vascular (with delay), non-compartment model analysis, bio-equivalence analysis as well as slow release formulations and in vivo correlation analysis of a total of 10 pharmacokinetic data analysis module, combined with literature data Contrast the use of the program as well as the 3P87 and WinNonlin software processing the results obtained. Results: The pharmacokinetics of the successful preparation of the condensed data processing program - PKSolver 1.0, the program, compared with the 3P87 and WinNonlin software, all the pharmacokinetic parameters of demand calculation results and the results are basically consistent model selection criterion. Conclusion: This program can be used in common reference to pharmacokinetic data analysis, more pharmacokinetic data analysis module to be further developed. Keywords: pharmacokinetics; data analysis; Excel; PKSolver 1.0 At present pharmacokinetic data processing, there are many professional software to choose from, such as the most widely used WinNonlin and 3P87/97 procedures, the use of these powerful professional software, even the conventional pharmacokinetic data processing, but also to complex operations, and most new drug research sector researchers are often afraid to learn the operation of professional software and settings. Excel is the most widely used statistical software, with a clear interface, easy to op