Gas Chromatography Measurement of borneol content of pearl pills and Stability.docVIP

 PAGE \* MERGEFORMAT 9 Gas Chromatography Measurement of borneol content of pearl pills and Stability Author: Ma Lin, WANG Yong-lin, Wang Aimin, Lan Yanyu, Li Yongjun, He Xun [Abstract] Objective: To establish a gas chromatography Pearl Pill borneol content method, and using this method the stability of borneol on the preparations studied. Methods: The large diameter FFAP quartz capillary column (30 m * 0.53 mm, 0.5 μ m) as column, high purity nitrogen (99.999%) as carrier gas; pre-column pressure 20 kPa, column temperature 130 ℃ , inlet temperature of 220 ℃ , hydrogen flame ionization detector temperature 250 ℃ ; hydrogen (99.99%) flow of 40 ml / min, air flow 400 ml / min. Results: Long brain in 0.25 ~ 0.75 g / L linear relationship was good, r = 0.999 9, recovery was 99.33%, RSD was 1.4%. Conclusion: Gas chromatography can be used as quality control of pearl pills; preparation of borneol placed at 30 ℃ , the following basic stability of high-temperature environments should be avoided. [Keywords:] pearls; borneol; chromatography, gas; Pearl Pill [Abstract] Objective: To establish a method for determining borneol content in Zhenzhu Dripping Pills, and to study the stability of borneol with this method. Methods: FFAP quarts capillary column (30 m * 0.53 mm, 0.5 μ m) was used to carry gas which was highly pure N2 (99.999%); The pre-column press was 20 kPa, and the temperatures of the column, the injector and the detector were 130 ℃ , 220 ℃ , and 250 ℃ respectively; The flow rates of hydrogen (99.99 %) and air were 40 ml / min and 400 ml / min respectively. Results: Bornyl alcohol showed a good linear relationship at the range of 0.25 ~ 0.75 g / L, r = 0.999 9. The average recovery rate was 99.33% and RSD was 1.4%. Conclusion: The method is sensitive, accurate and could be used in the quality control and the stability study of bornyl alcohol in Zhenzhu Dripping Pills. Borneol in the preparation is basically stable at the temperature below 30 ℃ , and the hot