Ginkgo flavone phospholipid complex on rat myocardial reperfusion injury in vascular endothelial.docVIP

 PAGE \* MERGEFORMAT 8 Ginkgo flavone phospholipid complex on rat myocardial reperfusion injury in vascular endothelial [Abstract] Objective: To investigate the ginkgo flavone phospholipid complex on myocardial ischemia-reperfusion injury of vascular endothelial protection. Methods: 40 healthy Wister rats were randomly divided into sham operation group, model group, ginkgo flavone group and ginkgo flavone phospholipid complex groups of 10, testing each group of plasma endothelin (ET1), prostacyclin (PGI2 ), thromboxane A2 (TXA2) levels and serum nitric oxide (NO), malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity. Results: The ginkgo flavone phospholipid complex 30min on myocardial ischemia-reperfusion 120min rats, can significantly reduce the serum NO and MDA levels, leaving SOD activity was enhanced, but also so that plasma ET1, TXA2 levels drop, PGI2 levels and PGI2/TXA2 were significantly increased, and the changes in flavonoids than significant. Conclusion: Ginkgo flavone phospholipid complex on rat myocardial reperfusion injury of vascular endothelium has obvious protective effect may be related to enhanced activity of antioxidant enzymes to reduce free radical oxidative damage of endothelial cells, reducing endogenous vasoactive substances ET1 release, PGI2/TXA2 mechanisms to correct imbalances. [Keywords:] Ginkgo flavonoids; ginkgo flavone phospholipid complex; myocardial ischemia-reperfusion injury; free radicals Ginkgo flavonoids (flavonoids) Department of Ginkgo biloba extract active ingredients, with a diastolic blood vessels, expansion of micro-circulation caliber, protect vascular endothelium, improving blood flow and so on. Mainly used in clinical coronary heart disease, angina pectoris, cerebrovascular disease, brain damage and other sequelae of treatment. Ginkgo flavone phospholipid complex is the ginkgo flavone and phospholipids under certain conditions, reaction of a class of material, its physical and chemical propertie