Glycosylated hemoglobin in the diagnosis of high-risk groups in the value of type 2 diabetes.docVIP

 PAGE \* MERGEFORMAT 12 Glycosylated hemoglobin in the diagnosis of high-risk groups in the value of type 2 diabetes Of: Zhang Jian, Yang Qing, Zhang Jinan, Chen Yu, Qin Qiu, Yang Jing, Yan Ni [Abstract] Objective To investigate the diagnosis of type 2 diabetes, glycated hemoglobin (HbA1c) of the reference value, and comparative analysis of fasting plasma glucose (FPG) and HbA1c for the diagnosis of sensitivity and reliability. Methods 108 patients with suspected type 2 diabetes (male 66 , female 42), using 1997 American Diabetes Association (ADA) standards for diagnostic criteria. by drawing receiver operating characteristic curve (ROC curve), FPG and HbA1c analysis and comparison of diagnostic sensitivity and specificity. Results HbA1c of the ROC The best cut point curve was 6.35%, sensitivity 78.1%, specificity 90.9%, area under the curve 0.9 (95% CI 0.84 ~ 0.96), positive likelihood ratio 8.6, negative likelihood ratio 0.24, positive predictive value 92.6% negative predictive value of 74.1%. FPG of the ROC curve the best cut point of 6.45mmol / L, sensitivity 89.1%, specificity 86.4%, area under the curve 0.93 (95% CI 0.88 ~ 0.98). When the HbA1cgt; = 6.35% , the diagnostic accuracy was 92.6%, while the FPGgt; = 6.45mmol / L when the diagnostic accuracy of 85.7%. Conclusion HbA1cgt; = 6.35% can be used as a diagnostic method of type 2 diabetes, and compared the diagnostic accuracy FPG higher than the FPG sensitivity is low. [Keywords:] glycosylated hemoglobin; diabetes; fasting glucose; glucose tolerance test (OGTT); receiver operating characteristic curve ABSTRACT: Objective To explore the reference value of glycated hemoglobin (HbA1c) for diagnosing type 2 diabetes and compare the diagnosis sensitivity and reliability between fast plasma glucose (FPG) and HbA1c. Methods A total of 108 subjects (66 males and 42 females) with risk factor for type 2 diabetes were included. The diagnosis of type 2 diabetes was based on the diagnostic criteria of