Green Qin solution on hyperuricemia uric acid metabolism in rats and the activity of.docVIP

 PAGE \* MERGEFORMAT 11 Green Qin solution on hyperuricemia uric acid metabolism in rats and the activity of Of: Meng Fengxian, Liu Shiju, HAZARD Haogui Xiang, Tao Xiaohua, Liu Hui, Sun Hua, Ni Qing, Zhang Runyun, Song Jinling [Abstract] Objective To observe the Green Qin solution on uric acid metabolism in rats with high serum uric acid and related enzyme activities. Methods 70 Wistar rats were randomly divided into normal group, model group, positive medicine group and the Green Qin solution of large, medium , low-dose group. adenine and ethambutol by gavage for modeling. positive drug group were 0.09 mg / kg body weight fed with colchicine, high-dose group were given 5 g / (kg · d) liquid filling Qin Qing stomach, in the dose group were given 2.5 g / (kg · d) Green Qin liquid gavage, dose group were 1.25 g / (kg · d) Green Qin liquid gavage. using phosphotungstic acid method for the determination of blood uric acid and uric acid, Determination by enzyme xanthine oxidase (XOD) and adenosine deaminase (ADA) levels. The results of colchicine and Green all have significantly reduced fluid Qin hyperuricemia role of serum uric acid level in rats, but difference was not statistically significant (Pgt; 0.05), reduce high uric acid in the blood of ADA activity in rats the role, positive group and the Green Qin solution of large, medium, low-dose group was significantly lower than model group (P lt;0.05, P lt;0.01), and Green Qin solution, low dose group were significantly lower than serum ADA positive drug group (P lt;0.05), positive drug group and the Green Qin solution of large, medium, low dose group XOD content in the blood were significantly lower than model group (P lt;0.05, P lt;0.01). Conclusion Qin green liquid with hyperuricemia in rats significantly reduced serum uric acid level and blood ADA, XOD active role in reducing hyperuricemia the role of ADA activity in blood, blue Qin solution, low-dose group was significantly better than the positive drug