Guan Mu Tong and their processed products in the content change of aristolochic acid A.docVIP

 PAGE \* MERGEFORMAT 8 Guan Mu Tong and their processed products in the content change of aristolochic acid A [Abstract] Objective To investigate the manshuriensis medicinal and processed products of aristolochic acid A change in the content. Methods using high performance liquid chromatography (HPLC) detection. Chromatographic conditions: column for the Lichrospher-C18 column (4.6 mm * 200 mm, 5 μ m), mobile phase was methanol -0.1% acetic acid solution (70:30), flow rate 1.0 ml / min, detection wavelength 310 nm, column temperature at 30 ℃ . Results Chaojiao, talcum powder, fried, fried three kinds of processed products of bran in aristolochic acid content than those of A decrease in health products and processed products of talc powder after frying to reduce the highest rate. Conclusion This three kinds of processing methods to reduce manshuriensis the content of aristolochic acid A, to achieve the purpose of reducing toxicity. [Keywords:] Guan Mu Tong processed products of aristolochic acid A Guan Mu Tong plant northeast of Aristolochiaceae Aristolochia Aristolochia manshuriensis Kom.’s Dry cane, mainly containing aristolochic acids. In recent years, with regard to renal damage caused by aristolochic acid is more coverage, known as aristolochic acid nephropathy [1]. Although Chinese medicine containing aristolochic acid nephrotoxicity is well established, but such a long history of Chinese medicine, the exact efficacy and clinical use of extensive, if Yinyefeisi to take a uniform approach to the abolition of all traditional Chinese medicine containing aristolochic acid in clinical use, is neither possible nor realistic. The application is based on traditional Chinese medicine concocted and compatibility features of the compound. With regard to manshuriensis reduce the toxicity of the compound of compatibility there are a lot of research, but whether the traditional processing methods to reduce its toxicity yet to see the system of reporting. In order to