Guinea pig model of allergic rhinitis nasal mucosa of the pathological changes.docVIP

 PAGE \* MERGEFORMAT 15 Guinea pig model of allergic rhinitis nasal mucosa of the pathological changes Abstract observe the pathological changes of nasal mucosa of allergic rhinitis. Methods: The olive oil will  2,4  toluene diisocyanate dubbed the concentration of 10% of the solution as a sensitizer, intranasal, guinea pig animal models of eight cases of allergic rhinitis. 8 cases of normal guinea pigs as controls. Sensitized the end, the model is successful, take two sets of nasal mucosa, pathological changes observed under light microscope. Results: The model group nasal epithelial shedding, goblet cell hyperplasia, squamous epithelial tissue transformation, epithelial necrosis, lamina propria and submucosa gland hyperplasia, vascular expansion, tissue edema, and see the features of eosinophils, mast cells infiltration, such pathological changes and clinical manifestations of allergic rhinitis generally coincide. The control group nasal epithelium of pseudostratified ciliated columnar epithelium, continuous, complete, clear, showing a normal mucosal epithelium, lamina propria and submucosa. Conclusion: The nasal mucosa of allergic rhinitis appears characteristic pathological changes of inflammation. Keywords: allergic rhinitis nasal mucosa pathology animal disease models A 〖KH 9.2mmD] Pathological changes of the nasal mucosa of guinea pigs with allergic rhinitis [ABSTRACT] Objective: To investigate the pathological changes of the nasal mucosa in guinea pigs with allergic rhinitis. Methods: Toluene 2, 4  diisocyanate was mixed with florence oil in a concentration of 10% and this solution was dripped into the nostrils to induce a sensitization process. Eight guinea pigs were established with allergic rhinitis by this solution and another 8 were used as controls. Nasal mucosa tissues were observed under a light microscope. Results: False multiple coat cilium columnar epithelial cells of the nasal mucosa in the control group were