Haemophilus influenzae resistance and resistance mechanisms.docVIP

 PAGE \* MERGEFORMAT 26 Haemophilus influenzae resistance and resistance mechanisms Author: Zhu Yan Yan, Hua-chun Zhen, Hui-Min Yu Keywords: Haemophilus influenzae; resistance; resistance mechanisms The current worldwide bacterial resistance to antibiotics in recent years the field of medical science research hot issue. Hib (Haemophilus influenzae, Hi) is a common pediatric respiratory tract infection pathogens, clinical resistance to commonly used antibiotics on the rise, causing widespread concern of the medical profession. Following the β-lactamase-negative ampicillin-resistant Hi (BLNAR) found that, after another after another around the world reported the emergence of multiple drug-resistant strains. In this paper, the resistance status of Haemophilus influenzae and its resistance to antibiotics commonly used machine to produce a synthesis. A general situation of Haemophilus influenzae Hi Typing of the common methods of biotype, serotype, and a variety of capsular types, including capsular type / serotype pairs of Hi pathogenicity studies and vaccine development of great significance. According to a type of bacteria cell wall outside the presence or absence of capsular polysaccharide can be categorized into capsules can be divided into Hi-and non-free capsule typing into two categories, then the former may be based on their capsular polysaccharide antigens of different, divided into a, b, c, d, e, f 6 serotypes. Studies have shown that different times in different regions serotypes Hi there is a big regional differences. By direct in situ polymerase chain reaction (ISPCR) hybridization, the 20th century, 50 to 60 years the detection rate of Hib was 14.3%, and 80 years to 2002, the detection rate of Hib was 20.5% [1]. CHEN Min-jun et al [2] with the Hib antigen latex agglutination test for Beijing, Shanghai and Guangzhou strains studied and found that Hib three regions accounted for 1.8%, 32.3% and 6.5% respec