Headspace Capillary GC Determination of cefpirome sulfate in the organic solvent residue.docVIP

 PAGE \* MERGEFORMAT 8 Headspace Capillary GC Determination of cefpirome sulfate in the organic solvent residue [Abstract] Objective To determine the cefpirome sulfate in acetone, dichloromethane, ethyl acetate three kinds of organic solvent residue method. Methods headspace capillary GC method was used to DM  624 capillary gas column, FID detector were determined. The results of acetone, ethyl acetate two kinds of solvents at the 0.1 ~ 2.5 mg / mL, methylene chloride at 0.012 ~ 0.3 mg / mL range showed good linear relationship. Acetone recovery was 100.1% (RSD = 2.1%), dichloromethane recovery was 99.2% (RSD = 1.0%), ethyl acetate recovery was 99.4% (RSD = 1.0%). Conclusion This method is accurate and reliable, simple and sensitive, reproducible, and can be used cefpirome sulfate in the determination of residual organic solvents. [Keywords:] cefpirome sulfate; of organic solvent residue; capillary gas chromatography; headspace Abstract: Objective To establish a capillary GC with headspace injection for the analysis of residual organic solvents, namely acetone, dichloromethane and ethyl acetate, in cefpirome sulfate. Methods DM  624 capillary column was used. The detection was carried out with FID detector. Results Acetone and ethyl acetate showed a good linear correlation in range of 0.1 ~ 2.5 mg / mL, and dichloromethane had good linearity in the concentration range of 0.012 ~ 0.3 mg / mL. The recoveries of acetone, dichloromethane and ethyl acetate were 100.1% (RSD = 2.1%), 99.2% (RSD = 1.0%) and 99.4% (RSD = 1.0%), respectively. Conclusion This method is accurate, reliable and simple for the determination of residual organic solvents in cefpirome sulfate. Keywords:: cefpirome sulfate; residual organic solvent; capillary GC; headspace injection Cefpirome sulfate is the fourth-generation cephalosporins, applies to this product-sensitive staphylococcus, streptococcus, fecal Enterococcus, Peptostreptococcus spp, E. coli is, Haemophilus influenzae, Acin