High homocysteine and stroke research.docVIP

 PAGE \* MERGEFORMAT 10 High homocysteine and stroke research Homocysteine is a sulfur-based amino acid. A large number of studies have shown that high hyperhomocysteinemia in atherosclerosis and thromboembolic diseases such as cerebrovascular disease, coronary heart disease and venous thrombosis, etc. play an important role in the pathogenesis has been considered to be independent risk factors 1. This will be high in recent years, the relationship between homocysteine and stroke in the study are reviewed. Mainly include the relationship between Hcy and cerebral vascular disease, affecting factors, mechanism and treatment recommendations. 1, Hcy and cerebral vascular disease Most of the studies confirm that moderate the relationship between the elevated Hcy and cerebral infarction, myocardial infarction, deep vein thrombosis and peripheral vascular disease risk related to the rise [1]. Plasma Hcy levels of the general population is higher than 15μ mol / L were less than 5%, while in stroke and other thromboembolic diseases were up to 50% [2]. Temple and other reviews from 1966 to 1999 literature, with 30-40% of cerebrovascular disease who have elevated Hcy levels [3]. Patients with acute stroke average Hcy concentration was 14.5 ± 4.5μ mol / L, with atherosclerosis risk patient 14.6 ± 6.2μ mol / L and healthy control group was 10.3 ± 3.1μ mol / L [4]. Yoo, etc. with the MRA examination revealed cerebral blood vessels narrow 2-3 at the patient’s Hcy was significantly higher than a narrow or not narrow infarction patients. Multiple Logistic regression analysis showed moderately Hcy elevated and vascular stenosis few significantly associated [5]. Matsui, etc. In the 153 cases of older people found that adjusted for age, sex, hypertension, renal function and history of tobacco and alcohol, etc., the high tHcy levels and only in the silence can be found on MRI cerebral infarction (silent brain infarction, SBI) was significantly related to [6]. Aronow and other p