Histone deacetylases (HDACs) Progress in.docVIP

 PAGE \* MERGEFORMAT 24 Histone deacetylases (HDACs) Progress in [Abstract] The study of cancer epigenetics, histone acetylation modification of tumor development plays an important role. Normal cells within the body of the event of a nuclear histone acetylation and deacetylation of the imbalance, which will lead to normal The cell cycle and cell metabolism changes in behavior induced by the tumor. histone deacetylation (histone deacetylases, HDACs) to the catalytic histone acetylation in maintaining histone acetylation and Deacetylation of balance, and cancer-related genes transcription, cell proliferation, differentiation and apoptosis, and many other processes are closely related. this histone deacetylase from the structural classification of HDACs with tumor occurrence and development of relations between the two aspects of HDACs were reviewed. [Keywords:] histone deacetylases (HDACs); tumor; epigenetic Abstract: The modification for histone acetylation is of great importance for formulation and development of tumors in the epigenetic study of tumors. The disequilibrium of histone acetylation and deacetylation may cause some changes of cell cycle and cell metabolism. Histone deacetylases (HDACs) catalyze the deacetylation of histones, and maintain the equilibrium between histone acetylation and deacetylation as well. They are related to many regulation processes containing transcription of oncogene, cell cycle, apoptosis and so on. The structure classification of HDACs and the relationship between the HDACs and the formation and advancement of tumor were reviewed in this paper. Keywords:: histone feacetylases (HDACs); tumor; epigenetics Tumors is a complex pathological process by multiple factors, including individual genetic factors, environmental factors, physical and chemical factors, molecular biological factors and so on. With the rapid development of life sciences and related mechanisms and onset of tumor disease mechanism to carry out