HMP of spontaneously hypertensive rat heart protective effect.docVIP

 PAGE \* MERGEFORMAT 18 HMP of spontaneously hypertensive rat heart protective effect Study: Friends of Hu sent, Tiandeng Ke, Chen Gang collar, Liu Jun, can swallow, Bian card [Abstract] Objective To investigate the HMP (HMP in spontaneously hypertensive rats (SHR cardioprotection and its possible mechanism. Methods HMP 6 weeks old SHR were divided into treatment group, hypertension model group, the WKY rats As a normal blood pressure groups, each divided into 3 batches at 3 time points (6 weeks delivery, delivery 14 weeks, rats were killed 9 weeks withdrawal, tail cuff blood pressure measurement, FRAP method for total antioxidant capacity of heart tissue, measured by RT-PCR study of inflammation-related factors ICAM-1, VCAM-1, IL-1 and TNF @ mRNA expression, Western Blot and ELISA, inflammation related factors were investigated ICAM-1, VCAM-1 and IL-1, TNF @ protein expression. Results HMP no significant antihypertensive effect on SHR, but SHR heart tissue can increase the total antioxidant capacity. PCR, Western Blot and ELISA shows give HMP 6 weeks and 14 weeks, could significantly inhibit the inflammation associated factor SHR heart ICAM-1, VCAM-1 m RNA expression of ICAM-1 expression, administration of 14 weeks, could significantly inhibit the inflammatory factors associated IL-1, TNF @ mRNA expression and protein expression, drug withdrawal after 9 weeks, still inflammatory factors associated ICAM-1, TNF @ mRNA expression and protein expression of ICAM-1. Conclusion HMP independent step-down outside the cardioprotective effect of SHR, which may inhibit the heart tissue and reduce tissue inflammation and oxidative stress . [Keywords:] HMP heart inflammation in spontaneously hypertensive rats Hypertension Abstract: ObjectiveTo investigate the protective effect of Heart-protecting musk pill (HMP) on heart in spontaneously hypertensive rats (SHR), and its possible mechanisms. Methods6 wk-old male SHR were randomly dicided into the HMP treatment gr