Hyoscyamus niger acute toxicity anti-inflammatory and analgesic effect.docVIP

 PAGE \* MERGEFORMAT 10 Hyoscyamus niger acute toxicity anti-inflammatory and analgesic effect Author: Wang Yan BAI Zong Lei Li Jun Ji-Ping Chen Jia Tianzhu [Abstract] Objective: To investigate the acute toxicity of Hyoscyamus niger extract, anti-inflammatory and analgesic effect. Methods: The maximum amount for the highest concentration administered mice, to validate its acute toxicity, determination of maximum tolerated dose (MTD); to mouse hot-plate test, writhing in mice to observe its analgesic effect; to xylene-induced mouse ear swelling was observed by its anti-inflammatory effect. Results: Determination of acute toxicity tests in mice on the drug’s maximum tolerated dose (MTD) for 200g * ml-1, a human daily dosage of 8333 times; the experimental data by the t test statistic, indicating that the analgesic effect of Hyoscyamus niger, also can inhibit the inflammatory response. Conclusion: Hyoscyamus niger toxicity in mice is very small, and has a good analgesic, anti-inflammatory effects. [Keywords:] henbane maximum tolerated dose acute toxicity test anti-inflammatory analgesic Researches in Acute Toxicity, Anti-in flammatory and Antalgic Effect of Seeds of Hyoscyamus lnger Hyoscyamus niger (Semen Hyoscyami) for the Solanaceae plant henbane Hyoscyamus niger L. dry mature seeds, formerly known as ‘Belladonna child’, also known as ‘cross-Don’. Weixin, warm in nature, there are big drug, are used for traditional Chinese medicine before seen in ‘Shen Nong Ben Cao Jing’, in the final heart, stomach, liver meridian. With a spasm pain, soothe the nerves Dingchuan effect, for stomach cramps pain, cough and frantic embolism [1]. Modern Clinical commonly used in anti-cancer agents, because patients with multiple cancers associated with pain, but also the traditional analgesic effects, so studies of its analgesic effect. Also because there are Dingchuan effect, respiratory disease, often accompanied by inflammation, concluded that the medicine should have a