Hypoxia inducible factor-1 and endothelial nitric oxide synthase Progress.docVIP

 PAGE \* MERGEFORMAT 15 Hypoxia inducible factor-1 and endothelial nitric oxide synthase Progress [Abstract] investigate the mechanism of high altitude hypoxic tolerance groups, many of the functions associated with hypoxia tolerance developed rapidly study genes, hypoxia inducible factor -1 @ (HIF-1 @) and endothelial nitric oxide synthase enzyme (NOS3) is one of the two major genes. At present, some studies have shown that in high altitude adaptation in these genes play an important role. In this paper, HIF-1 @ and NOS3 reviewed the research progress, and to explore its high altitude adaptation and other related diseases, in order to provide a basis for future prospective research information. [Keywords:] Hypoxia inducible factor -1 @; endothelial nitric oxide synthase; progress Abstract: Many research about the functional genes related to hypoxia tolerance have developed rapidly with the study of the mechanism of high altitude hypoxic tolerance. For example, hypoxia-inducible factor-1 @ (HIF-1 @) and endothelial nitric oxide synthase (NOS3 ) are the two major genes. At present, some studies have shown that these genes play an important role in high altitude adaptation. In this paper, we reviewed the research progress of HIF-1 @ and NOS3 to investigate the relationship between the high altitude adaptation and some diseases, and provide the basic information for future prospective studies. Keywords:: hypoxia inducible factor-1 @; endothelial nitric oxide synthase; advancement Studies have shown that hypoxia inducible factor -1 @ (HIF-1 @) and endothelial nitric oxide synthase (NOS3) gene is involved, regulation of many diseases, especially in the pathophysiology of altitude sickness. As genetics and molecular biology technology development, research into the molecular causes of disease stages to determine the genetic basis of disease become a hot research at home and abroad. adapt to high altitude in the study of many candidate genes, because of