Hypoxia-inducible factor 1α and Endostatin in breast invasive ductal carcinoma and their correlation.docVIP

 PAGE \* MERGEFORMAT 17 Hypoxia-inducible factor 1α and Endostatin in breast invasive ductal carcinoma and their correlation 【Abstract】 Objective: To investigate the invasive ductal carcinoma of hypoxia-inducible factor  1α and Endostatin expression of the inherent correlation between breast cancer and its relationship with biological behavior relationship. Methods: Immunohistochemistry SP method detected 86 cases of breast invasive ductal carcinoma and 12 cases of benign breast tumor tissue hypoxia inducible factor  1α and Endostatin expression. Results: 86 cases of breast invasive ductal carcinoma of hypoxia-inducible factor  1α positive expression rate of 52.33% (45/86), Endostatin positive expression rate of 46.51% (40/86), both benign tumor in the breast tissue not expressed (0 / 12); hypoxia-inducible factor  1α and Endostatin expression was significantly higher than in benign breast tumor organizations, hypoxia-inducible factor  1α and Endostatin expression rate and invasive ductal breast cancer clinical stage, pathologic histological grade, tumor size, lymph node metastasis, 5-year survival rate is closely related (P lt;0.01), hypoxia-inducible factor  1α expression and Endostatin was negatively correlated (P lt;0.01). Conclusion: In breast invasive ductal carcinoma, tumor angiogenesis via hypoxia-inducible factor  1α increase tumor angiogenesis factor, or the angiogenesis inhibitor Endostatin reduced the tumor angiogenesis factor, to achieve a malignant tumor development or improvement . Hypoxia-inducible factor  1α and the expression may be assessment of Endostatin invasive ductal breast cancer clinical stage, histological grade, tumor size, lymph node metastasis, 5-year survival and other biological important indicators. Keywords: breast cancer; hypoxia-inducible factor  1α; Endostatin; immunohistochemistry Rapid growth of breast cancer tumor cells to the proliferation of normal tissue invasion and metastasis characte