Hydroxyapatite orbital implants vascular endothelial growth factor expression.docVIP

 PAGE \* MERGEFORMAT 14 Hydroxyapatite orbital implants vascular endothelial growth factor expression Of: Fang Teng, Li Qiuming, LU Jian Xiang, Shuhua E, Liu Fang [Abstract] Objective: To investigate the vascular endothelial growth factor (vascular endothelial growth factor, VEGF) and hydroxyapatite (hydroxyapatite, HA) orbital implants fibrovascularization the relevance of the formation, and the dexamethasone suppression hydroxy apatite Stone implants fibrovascularization mechanism. Methods: 20 rabbits were randomly divided into experimental group and control group, n = 10 in each group with HA implants implanted in rabbit eyes. tobramycin drops after eye drops 4 times / d, from the experimental group, 48h after peribulbar injection of dexamethasone every other day and 0.5mg end of the experiment, and the growth of the conjunctiva were observed in the experimental group and control group respectively after 3,7,14 , 21,28 d removal of two HA implants by immunohistochemistry detected positive expression of VEGF. Results: hydroxyapatite implants fibrovascularization VEGF expression and there is a significant correlation. After 14d, the experimental group HA significantly reduced infiltration of inflammatory cells, VEGF expression in the experimental group was significantly lower than the control group. Conclusion: Hydroxyapatite implants fibrovascularization closely related with the inflammatory response, VEGF may be involved in the formation of fibrovascularization, dexamethasone may implants by inhibiting inflammation and VEGF expression. [Keywords:] vascular endothelial growth factor, hydroxyapatite, orbital implants, fiber vascularization, inflammation Abstract AIM: To investigate the relevance of formation of fibrovascularization between vascular endothelial growth factor (VEGF) and hydroxyapatite (HA) orbital implants; and the mechanism of dexamethasone suppression on fibrovascularization of HA implants. METHODS: Twenty rabbits were randomly div