Human immunodeficiency virus receptor and coreceptor.docVIP

 PAGE \* MERGEFORMAT 18 Human immunodeficiency virus receptor and coreceptor Receptors and Coreceptors of Human Immunodeficiency Virus Keywords: Acquired immunodeficiency syndrome (AIDS), Human immunodeficiency virus, Receptor, Coreceptor Human immunodeficiency virus (Human Immunodeficiency Virus, HIV) is a pathogen that causes AIDS. Higher mortality due to disease, there is currently no widely accepted and effective treatment methods for AIDS around the world attach great importance to. When HIV infection, HIV first with the target cell receptors (receptor) combined in order to enter the cells and in their breeding. Therefore, sufficient knowledge of HIV receptors and co-receptor (coreceptor), to control HIV infection and spread is essential. 1 HIV receptor As early as 10 years ago, people discovered that antigen with anti-CD4 monoclonal antibody in vitro can prevent the virus from binding to the cell and viral infections; subsequently found to be CD4 gene into the cells did not express CD4 molecules, allowing the cell expression of CD4 protein [1], this expression of CD4 antigen in HIV infected cells can be, so that is the HIV receptor CD4. But then, through study found, HIV envelope glycoprotein precursor gp120 and gp160-transcriptional cut into gp41, the two non-covalently connected together to form gp120 and gp41 by three oligomers formed by [2 ], where the virus can cross the envelope gp41. gp120 with the host cell’s CD4 molecule with high affinity, through both the identification, virus attachment to the cell surface gp41 and make the configuration changes, triggered by cell fusion, and expressed gp120 of infected cells and uninfected of normal CD4 cells to form syncytia (syncytium), which led to the normal cell death [2]. The 2 HIV co-receptor 2.1 co-receptor and cell-tropic strains of Interval of ten years later, in 1996, found that CCR5 and CXCR4 co-receptor for HIV-. Because the CD4 molecule itself