Human leukocyte antigen and hepatitis B virus.docVIP

 PAGE \* MERGEFORMAT 19 Human leukocyte antigen and hepatitis B virus [Keywords:] human leukocyte antigen; gene polymorphism; Hepatitis B Hepatitis B (HBV for short) is the world’s widespread infectious diseases, according to incomplete statistics, at least 20 million people worldwide have been infected with hepatitis B virus (hepatitis B virus, HBV), about 300 million who become chronically infected persons, in our country is a common infectious disease epidemic is very broad, by their infected patients, there may be different disease manifestations such as acute hepatitis, chronic hepatitis, cirrhosis and liver cancer, the disease has there are familial, and the probability of infection is greater than between parents and couples, a serious threat to human health [1]. Humans infected with HBV, the clinical outcomes there are different mechanisms is not yet clear [2].Studies have shown that HBVReplication does not directly damage liver cells ,Of their illness, and there are different clinical course and performance depends mainly on the immune status of individuals [ 3,4], That is, the ability of the immune response by an individual decision; and decided to host immune response capacity of the most important genetic factor is the HLA allele polymorphism. In recent years, studies have shown that human leukocyte antigen (human leucocyte antigen, HLA) complex and HBV infection in certain relations exist between certain types of HLA genotype and chronic HBV infection related to [5], anti-HBV immune response by the HLA Ⅰ type, Ⅱ genes influence [6,7]. In this paper, HLA genotypes associated with HBV infection, HLA gene and hepatitis B vaccine response in reaction to the relationship between the two on the relevant reports in recent years to make a brief review. 1 HLA complex Major histocompatibility complex (major histocompatibility complex, MHC) is a vertebrate chromosome encoding a major histocompatibility antigen, control of mutual recognition between ce